WebJun 17, 2024 · Recent attempts to generate targeted LNPs that, in addition to accumulating in the liver, are directed to other cells as well 4,5,9 generated promising results and … WebFeb 9, 2024 · Fibrosis affects millions of people with cardiac disease. We developed a therapeutic approach to generate transient antifibrotic chimeric antigen receptor (CAR) T …
Polymer- and lipid-based gene delivery technology for CAR T cell ...
WebApr 19, 2024 · Specifically, mRNA encoding a T-cell receptor targeting the fibroblast activation protein (FAP) was encapsulated within lipid nanoparticles (LNPs) that were … WebJan 7, 2024 · The efficacy of these in vivo–reprogrammed CAR T cells was evaluated by injecting CD5-targeted LNPs into a mouse model of heart failure. Efficient delivery of … tire recycling colorado springs
CAR T cells produced in vivo to treat cardiac injury Science
WebJan 1, 2024 · They evaluated a modified nucleoside-containing mRNA encoding a CAR to attack fibroblast activation protein (FAP) packaged into a CD5-targeted LNP (Fig. 8 a). After the good results obtained in T cells transfection (81% transfection efficiency), the authors verified if the LNPs improved cardiac function in an established murine hypertensive ... WebFeb 6, 2024 · A landmark Nature paper in 2024 first demonstrated the use of CAR-T cell therapies against FAP, a fibrosis–related target. The work came out of the Jonathan Epstein lab at Penn, and a follow-up study published in early 2024 built on the past work to establish in vivo activity of CAR-T cells after delivery (IV, CD5-targeted LNPs) of an anti-FAP … WebRecently, mRNA-encoded FAP (fibroblast activation protein) CAR was formulated with CD5-targeted LNPs, and specifically delivered into a mouse model of heart failure. This approach successfully produced CD5+ CAR T cells in vivo, reducing fibrosis and restoring cardiac function in the mouse model . Altogether, these impressive outcomes suggest ... tire recycling centers in pa